Regenerative Medicine

Regenerative injection therapy for tendons, ligaments, muscles and spine conditions.

About Regenerative Injection Therapies (RIT). 

Regenerative injections broadly deals with the use of biologic materials to enhance the body's own repair mechanisms to help heal previously non-reparable tissues.  The goal of these non-surgical procedures is to help heal the source of pain, not to simply mask it.  The exact mechanism is evolving, but science points toward enhancing and stimulating healing and stabilizing factors of the local tissues.

Regenerative injection treatments offer a viable alternative for individuals considering elective orthopedic surgery or joint replacement due to arthritis or injury.  Patients experience very little down time and they typically avoid the long, painful rehabilitation periods that can follow surgery.  Since 2014, Regenerative Spine & Musculoskeletal Medicine has provided state of the art regenerative cellular therapies to help patients find relief from pain without invasive surgeries.

The Procedures:

Platelet Rich Plasma Therapy (PRP):

PRP uses concentrated platelets from the patient's own blood to harness the body's ability to heal through the aid of growth factors.  PRP is injected directly into the injured tissue, stimulating the body's same healing response, but in a much more potent form.  You may gain considerable to complete relief after the first PRP injection.  In some cases, especially when the problem has been chronic or severe, additional PRP injections could be necessary.

Cellular Therapy: Stem cells (MSCs) are readily available and can be harvested from your bone marrow and fat tissue through a needle. Cellular therapy is also available from commercial products.  Once injected into an area of injury, cells secrete bioactive molecules to modulate repair and offer the potential to regenerate injured cartilage, ligament, tendons, or muscle.  Stem cells can be thought of as the manager of your body’s innate healing potential.  Many times only one injection is needed.  If there is an incomplete response to treatment additional injections may be advised.

Bone Marrow Aspirate:

Bone marrow aspirate(BMA) is a non-surgical regenerative cellular (aka stem cell) procedure in which cells are obtained from the patient's own bone marrow through a needle.  These cells are then injected into the patient's damaged joint, disc or cartilage injury.

Lipo Aspirate Cellular Injection:

Lipo aspirate cellular (aka stem cell) therapy is a gentle process that uses your body's own fat tissue to cushion and support areas of injury or damage as your body heals itself. The fat is taken from the stomach, flank or thigh areas using a local anesthetic.  The harvested fat is then precisely injected into the patient's injured areas using ultrasound or x-ray guidance.  It is especially effective for areas where there are soft tissue defects such as tears or arthritis.


Prolotherapy involves injecting a "proliferate" (usually dextrose) into weakened or injured joints, ligaments or tendons.  Prolotherapy causes activation of the inflammatory process, which is the body's natural healing process to strengthen ligaments, tendons or other soft tissues.  Additional treatments repeat the process, allowing a gradual build-up of tissue to help restore strength to the area and relieve pain.  The average number of treatment sessions is between 3 and 6.

Perineural Injections:

Peri-neural injections involves injecting diluted dextrose solutions superficially along the pathway of chronically inflamed nerves.  Perineural Injections can be used for any part of the body where nerve pain exists.  After the first treatment, pain relief may initially last for a period of four hours to four days. Repeated treatments (usually 6-8 sessions) are necessary, given every 1-3 weeks.  This type of injection is done in the office without the use of xray and ultrasound guidance.

What parts of the body can benefit from regenerative treatments?

Spinal Injections:

Spinal procedures can be performed with dextrose, platelet/growth factors, or cellular therapy for those who wish to avoid the effects of steroids.  Epidural nerve blocks, spine ligaments, facet joint, sacroiliac joint and intervertebral disc injections with platelets/growth factors may be performed. The injection is performed in the same manner as conventional spine injections with the use of x-ray guidance to ensure accurate placement of the treatment.

Joint, tendon, ligament, muscle Injections:

Musculoskeletal injections can be performed with dextrose, platelet/growth factors, or cellular therapy for those who wish to avoid the effects of steroids.  Whenever appropriate the injection is performed with the use of x-ray or ultrasound guidance along with full safety and sterile precautions.

What conditions can benefit from regenerative injections?

  • Arthritis
  • Sport injuries
  • Tendon injuries/tears
  • Tennis/golfers elbow
  • Rotator cuff injury
  • Patellar tendon
  • Meniscus tears
  • Achilles tendon
  • Plantar fasciitis
  • Ligament injuries/sprains
  • Labral tears (shoulder/hip)
  • Joint pain/arthritis
  • Neck pain
  • Back pain
  • Spinal disc disease


Will insurance cover my Regenerative Injection?

Insurance companies will not pay for the cost of the Regenerative treatment.  The cost of your injection can be discussed after your visit once you and the provider have decided on the most appropriate treatment option for you.


What sets Regenerative Spine & Musculoskeletal Medicine apart from others?

  • Use of image guidance with x-ray or ultrasound to ensure precise needle placement optimizing results.
  • Fellowship training in spine and orthopedic medicine.
  • Integration of cutting edge research and holistic medicine.
  • Personalized care in a small office setting.

As the popularity of RIT grows, other medical professionals are beginning to perform these procedures, with great variation in training and background.  Renée S. Melfi, M.D. is a physician specializing in non-surgical spine, orthopedic and musculoskeletal performance and function.  With three national board certifications and Fellowship training in interventional spine and musculoskeletal medicine, Dr. Melfi has been performing spine and orthopedic injections since 2002. Dr. Melfi is also certified in Integrative Medicine and Acupuncture, and offers suggestions to enhance your results with recommendations for proper nutrition and supplements.

Your procedure at Regenerative Spine & Musculoskeletal Medicine is carefully chosen based on review of the latest evidence based medicine.  Image guidance with x-ray or ultrasound is used, when appropriate, to confirm accurate placement of cellular therapy to optimize your results.

Call today for your appointment and a premier experience in Regenerative Injection therapy in Central New York 315-701-4000.